Glycyrrhiza Glabra Extract
Glycyrrhiza glabra (Licorice) is a favourable herb used in food and medicinal remedies for
thousands of years. This herb has long been valued as a demulcent (soothing, coating agent),
to relieve respiratory ailments (such as allergies, bronchitis, cold, sore throats and
tuberculosis), stomach burn including heartburn from reflux or any other cause, gastritis,
inflammatory disorders, skin diseases and liver problems. Glycyrrhiza
glabra contains a variety of substances.
The behavior of Glycyrrhiza glabra extract use about hepatoprotective and
antioxidant agent properties was supported in fish. Nonetheless, the skin
whitening, skin depigmenting, skin lightening, antiaging, anti-erythemic, emollient, anti-acne, a potential cancer
chemopreventive agent, cardioprotective effects
and photoprotection effects were mainly attributed to liquorice extract.
This extract has attenuates the hepatotoxic effect of CCl4.
Glabridin, from Glycyrrhiza glabra (Licorice) was shown to inhibit
both melanogenesis and inflammation. It was
found to have tyrosinase inhibitory activity and demonstrated efficacy
in reducing UV radiation induced inflammation in animal models. An
in vitro study revealed that glabridin inhibits tyrosinase activity in cultured B16 murine melanoma cells at concentrations of 0.1 to 1
mcg/ml, with no detectable effect on their DNA synthesis. Glabridin
was also found to inhibit the superoxide anion production and
cyclooxygenase activities, in vitro. In animal model studies, topical
application of 0.5% glabridin was shown to inhibit UVB induced skin
pigmentation and inflammation in guinea pig skin.